Arizona Cardinals vs San Francisco 49ers · All-Time
17 meetings tracked · closing-line graded
RECORD
7-10
MEETINGS
17
ATS
6-4
O / U
7-3
Key Insights
- ▸San Francisco 49ers lead 10-7 across 17 tracked meetings.
- ▸Games have averaged 49.8 combined points.
- ▸Arizona Cardinals have been the better ATS side (6-4).
- ▸Strong Over trend: 7-3 O/U.
Year-by-Year Record
| Season | Games | Arizona Cardinals | San Francisco 49ers | ATS | O / U | Avg Total |
|---|---|---|---|---|---|---|
| 2026 | 1 | 0 | 1 | — | — | 66.0 |
| 2025 | 2 | 0 | 2 | 1-1 | 1-1 | 47.0 |
| 2024 | 2 | 2 | 0 | — | 1-1 | 59.0 |
| 2023 | 2 | 0 | 2 | — | — | 62.5 |
| 2022 | 2 | 0 | 2 | — | — | 49.5 |
| 2021 | 2 | 2 | 0 | — | 1-1 | 37.5 |
| 2020 | 2 | 1 | 1 | — | — | 38.0 |
| 2019 | 2 | 0 | 2 | — | — | 57.5 |
| 2018 | 2 | 2 | 0 | — | — | 39.5 |
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Frequently Asked Questions
What is the Arizona Cardinals vs San Francisco 49ers record all-time?▾
Across 17 all-time meetings, the San Francisco 49ers lead the series 10-7.
What is the ATS trend in Arizona Cardinals vs San Francisco 49ers games?▾
ATS: Arizona Cardinals are 6-4 vs the spread in these matchups. San Francisco 49ers are 4-6.
Do Arizona Cardinals vs San Francisco 49ers games go over or under?▾
Over/under: games between Arizona Cardinals and San Francisco 49ers have gone over 7 times and under 3 times, with an average combined score of 49.8.
When did Arizona Cardinals and San Francisco 49ers last play?▾
See Last Meetings section for detailed score, spread, and total data from the most recent Arizona Cardinals vs San Francisco 49ers games.
Where can I see the 5-year Arizona Cardinals vs San Francisco 49ers history?▾
A 5-year head-to-head page tracks every Arizona Cardinals vs San Francisco 49ers meeting from the last five full seasons. Link at the bottom of this page.
Data coverage: Trendline's head-to-head records include closing-line-graded games from 2018–2026. Older meetings aren't in this dataset yet.